Rare Cardiology News
Advertisement
Disease Profile
Neuroleptic malignant syndrome
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Unknown
Age of onset
All ages
ICD-10
G21.0
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Categories
Nervous System Diseases
Summary
Neuroleptic malignant
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Abnormal autonomic nervous system physiology | 0012332 | |
Extrapyramidal muscular rigidity | 0007076 | |
Fever | 0001945 | |
Hyperhidrosis |
Excessive sweating
Increased sweating
Profuse sweating
Sweating
Sweating profusely
Sweating, increased
[ more ] |
0000975 |
Mutism |
Inability to speak
Muteness
[ more ] |
0002300 |
30%-79% of people have these symptoms | ||
Drooling |
Dribbling
|
0002307 |
Poor swallowing
Swallowing difficulties
Swallowing difficulty
[ more ] |
0002015 | |
Elevated serum creatine kinase |
Elevated blood creatine phosphokinase
Elevated circulating creatine phosphokinase
Elevated creatine kinase
Elevated serum CPK
Elevated serum creatine phosphokinase
High serum creatine kinase
Increased CPK
Increased creatine kinase
Increased creatine phosphokinase
Increased serum CK
Increased serum creatine kinase
Increased serum creatine phosphokinase
[ more ] |
0003236 |
Fatigue |
Tired
Tiredness
[ more ] |
0012378 |
Leukocytosis |
Elevated white blood count
High white blood count
Increased blood leukocyte number
[ more ] |
0001974 |
Metabolic acidosis | 0001942 | |
Muscle spasm | 0003394 | |
Tachycardia |
Fast heart rate
Heart racing
Racing heart
[ more ] |
0001649 |
Tremor | 0001337 | |
5%-29% of people have these symptoms | ||
Acute kidney injury | 0001919 | |
Agitation | 0000713 | |
Anxiety |
Excessive, persistent worry and fear
|
0000739 |
Aspiration pneumonia | 0011951 | |
Chorea | 0002072 | |
Coma | 0001259 | |
Dehydration | 0001944 | |
Delirium | 0031258 | |
Elevated alkaline phosphatase |
Greatly elevated alkaline phosphatase
High serum alkaline phosphatase
Increased alkaline phosphatase
Increased serum alkaline phosphatase
[ more ] |
0003155 |
Elevated hepatic transaminase |
High liver enzymes
|
0002910 |
0001298 | ||
Hyperkalemia |
Elevated serum potassium levels
|
0002153 |
Hypernatremia |
High blood sodium levels
|
0003228 |
Hyperphosphatemia |
High blood phosphate levels
|
0002905 |
Hypertensive crisis | 0100735 | |
Hyperuricemia |
High blood uric acid level
|
0002149 |
Hypocalcemia |
Low blood calcium levels
|
0002901 |
Hypomagnesemia |
Low blood magnesium levels
|
0002917 |
Hyponatremia |
Low blood sodium levels
|
0002902 |
Hypotension |
Low blood pressure
|
0002615 |
Increased lactate dehydrogenase level | 0025435 | |
Myoglobinuria | 0002913 | |
Nasogastric tube feeding | 0040288 | |
Nausea | 0002018 | |
Oculogyric crisis | 0010553 | |
High urine protein levels
Protein in urine
[ more ] |
0000093 | |
Pulmonary embolism |
Blood clot in artery of lung
|
0002204 |
Rhabdomyolysis |
Breakdown of skeletal muscle
|
0003201 |
Rigors | 0025145 | |
Thrombocytosis |
Increased number of platelets in blood
|
0001894 |
Urinary incontinence |
Loss of bladder control
|
0000020 |
Vomiting |
Throwing up
|
0002013 |
1%-4% of people have these symptoms | ||
Bradycardia |
Slow heartbeats
|
0001662 |
Hypothermia |
Abnormally low body temperature
|
0002045 |
Sepsis |
Infection in blood stream
|
0100806 |
Low platelet count
|
0001873 |
Related diseases
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
|
---|
The differential diagnosis is of prime importance. It includes malignant hyperthermia of anesthesia, serotonin syndrome, parkinsonism hyperpyrexia syndrome, heat stroke, idiopathic malignant catatonia, infections (sepsis, meningitis, encephalitis), autoimmune disorders (limbic encephalitis with NMDA receptor antibodies, lupus cerebritis) delirium tremens, status epilepticus, salicylate poisoning, endocrinopathies, stroke, and brain trauma.
Visit the Orphanet disease page for more information.
|
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Merck Manual for health care professionals provides information on Neuroleptic malignant syndrome.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Neuroleptic malignant syndrome. Click on the link to view a sample search on this topic.
References
- Neuroleptic Malignant Syndrome Information Page. National Institute for Neurological Disorders and Stroke. April 2014; https://www.ninds.nih.gov/disorders/neuroleptic_syndrome/neuroleptic_syndrome.htm.
- Theodore I Benzer, MD, PhD. Neuroleptic Malignant Syndrome. Medscape Reference. February 2015; https://emedicine.medscape.com/article/816018-overview#a4.
- Eelco FM Wijdicks, MD. Neuroleptic malignant syndrome. UpToDate. May 2014; Accessed 7/14/2015.