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Disease Profile
Pediatric Crohn’s disease
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Pediatric onset Crohn's disease; Crohn's disease, pediatric
Categories
Digestive Diseases
Summary
Crohn's disease is a type of inflammatory bowel disease (IBD), the general name for conditions that cause inflammation in the gastrointestinal (GI) tract. Common signs and symptoms include abdominal pain and cramping, diarrhea, and weight loss. Other general symptoms include feeling tired, nausea and loss of appetite, fever, and
Treatment is aimed at relieving symptoms and reducing inflammation, and may include diet and medication, but some people require surgery.[1][2] Surgery often involves removal of the diseased segment of bowel (resection), the two ends of healthy bowel are then joined together (anastomosis). In about 30% of people who have surgery for Crohn’s disease symptoms may come back within three years and up to 60% will have recurrence within ten years.[4]
Treatment
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Adalimumab(Brand name: Humira) Manufactured by AbbVie Inc.
FDA-approved indication: Treatment of Juvenile IdiopathicArthritis . Reducing signs and symptoms and inducing and maintaining clinicalremission in patients 6 years of age and older with moderately to severely active Crohn's disease who have had an inadequate response tocorticosteroids or immunomodulators such as azathioprine, 6-mercaptopurine, or methotrexate.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Infliximab(Brand name: Remicade) Manufactured by Centocor, Inc.
FDA-approved indication: For reducing signs and symptoms and inducing and maintaining clinical remission in pediatric patients with moderately to severely active Crohn's disease who have had an inadequate response to conventional therapy.
National Library of Medicine Drug Information Portal
Medline Plus Health Information
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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Crohn's & Colitis Foundation of America
733 Third Avenue, Suite 510
New York, NY 10017
Toll-free: 1–800–932–2423
E-mail: [email protected]
Website: https://www.crohnscolitisfoundation.org/
Speak with a specialist by telephone at 888-MY-GUT-PAIN (888-694-8872) -
Pediatric Inflammatory Bowel Disease Foundation
50 Congress St.
Boston, MA 02109
E-mail: [email protected]
Website: https://pedsibd.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- Just Like Me! , a Web site for kids and teens with ulcerative colitis or Crohn's disease sponsored by the Crohn's & Colitis Foundation of America (CCFA).
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Pediatric Crohn's disease. Click on the link to view a sample search on this topic.
References
- Crohn's disease. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). September 2014; https://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/crohns-disease/Pages/facts.aspx.
- Walfish AE & Sachar DB. Crohn Disease. Merck Manual Consumer Version. 2017; https://www.merckmanuals.com/home/digestive-disorders/inflammatory-bowel-diseases-ibd/crohn-disease?qt=&sc=&alt=.
- Crohn disease. Genetics Home Reference. 2018; https://ghr.nlm.nih.gov/condition/crohn-disease.
- What is Crohn's Disease?. Crohn's & Colitis Foundation of America. 2016; https://www.ccfa.org/what-are-crohns-and-colitis/what-is-crohns-disease/.