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Disease Profile
Squamous cell carcinoma
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Carcinoma, squamous cell; Epidermoid carcinoma; Squamous cell skin cancer
Categories
Rare Cancers
Summary
Squamous
Treatment
- Curettage and desiccation scraping away the cancer and using electricity to kill any remaining cancer cells; this is used to treat cancers that are not very large or deep[1][2]
- Surgical excision cutting out of the tumor and stitching up the remaining
tissue [1] Radiation therapy (if the skin cancer is located in an area difficult to treat surgically)[1]- Microscopically controlled excision (Mohs surgery) - repeated cutting out of small pieces of tissue that are then examined microscopically to check if any cancer has been left behind; repeated application of this technique minimizes the removal of healthy tissue and is cosmetically more satisfying, especially if carried out with a
plastic surgeon as part of the medical team.[1][2] This is more likely to be used for skin cancers on the nose, ears, and other areas of the face.[2] - Cryosurgery freezing and killing the cancer cells[2]
- Skin creams and medications may be used to treat superficial (not very deep) squamous cell carcinoma.[2]
The outlook for small squamous cell lesions that are removed early and completely is extremely favorable, with about 95% cured if they are removed promptly.[1][2]
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Cetuximab(Brand name: Erbitux®) Manufactured by ImClone Systems Incorporated
FDA-approved indication: For use in combination with radiation therapy, for the treatment of locally or regionally advanced squamous cell carcinoma of the head and neck (SCCHN) and for use as a single agent for the treatment of patients with recurrent or metastatic SCCHN for whom
National Library of Medicine Drug Information Portal
Medline Plus Health Information
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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The National Coalition for Cancer Survivorship
1010 Wayne Avenue
Suite 770
Silver Spring, MD 20910
Toll-free: 888-650-9127
Telephone: 301-650-9127
Fax: 301-565-9670
E-mail: [email protected]
Website: https://www.canceradvocacy.org -
The Skin Cancer Foundation
149 Madison Avenue Suite 901
New York, NY 10016
Telephone: 212-725-5176
Website: https://www.skincancer.org/
Organizations Providing General Support
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American Cancer Society
250 Williams Street NW
Atlanta, GA 30329
Toll-free: 1-800-227-2345
Website: https://www.cancer.org -
Cancer Hope Network
2 North Road, Suite A
Chester, NJ 07930
Toll-free: 1-877-467-3638 (1-877-HOPENET)
Telephone: +1-908-879-4039
Fax: +1-908-879-6518
E-mail: [email protected]/
Website: https://www.cancerhopenetwork.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The American Cancer Society provides information on Squamous cell carcinoma. Please click on the link to access this resource.
- DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
Genetics of Skin Cancer–for health professionals (PDQ®)
Skin Cancer Treatment–for health professionals (PDQ®) - The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
In-Depth Information
- PubMed is a searchable database of medical literature and lists journal articles that discuss Squamous cell carcinoma. Click on the link to view a sample search on this topic.
References
- Carcinoma, Squamous Cell. NORD. April 20, 2008; https://www.rarediseases.org/rare-disease-information/rare-diseases/byID/764/viewAbstract. Accessed 6/22/2011.
- Squamous cell skin cancer. MedlinePlus. August 12, 2009; https://www.nlm.nih.gov/medlineplus/ency/article/000829.htm. Accessed 6/23/2011.
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